Another dog of an editor for large files (260MB) on a Mac. Still, for me, Mac Fiend is working best.

[Edited by citizenkane, January 10]

I'm a long-time user and think you get what you pay for. Though it has some quirks, it's a very power editor for both source code and very large text files.

I use UltraEdit as a text and HTML editor. It can be setup to colour code the HTML code and this makes code level editing much easier. Search and replace is about all I do with it so I can't speak about using it on programming code.