PaintTool SAI is not available for Mac but there are plenty of alternatives that runs on macOS with similar functionality. The best Mac alternative is Krita, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 50 alternatives to PaintTool SAI and many of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to PaintTool SAI are MediBang Paint, Adobe Photoshop, FireAlpaca and MyPaint.
HiPaint is a professional integrated drawing and coloring software specially designed for digital drawing creators. The intuitive and simple interface allows for easy and intelligent operation even for a newbie with a medium- or small-sized screen of a mobile device.
InfiniPaint is a collaborative, infinite space, infinite zoom, canvas note-taking/drawing app. Unlike many other infinite canvas apps, although there is a specific zoom-in level limit, there is no zoom-out limit (at least up until the point your computer runs out of memory).
Sketches is a perfect mix of beauty, simplicity and power, a truly unique combination you won't find anywhere else.
Seashore is an open source image editor for Mac OS. It features gradients, textures and anti-aliasing for both text and brush strokes. It supports multiple layers and alpha channel editing. It is based around the GIMPs technology and uses the same native file format.
Flame Painter is a unique paint program that lets you create original artworks with flame brushes.
Linea is an elegantly simple sketchbook for Apple devices optimized for use with Apple Pencil. It opts for a minimal interface with only the essential options, rather than overkill like many other apps.
MyBrushes Paint for Mac app allows you to paint on infinite canvas and PLAYBACK whole drawing.
Livebrush is a drawing application. It employs an easy-to-use brush tool that reacts to your gestures through the use of velocity and other motion controls. By combining simple motion controls with customizable brush styles, Livebrush offers a fun and unique way to create...
Qaquarelle is a very young opensource Qt4-based painting application that is supposed to provide a native way of painting with emulated traditional instruments, including watercolor simulation, full support for tablets and OpenGL-based processing in GPU.
Pro Paint for Mac is the realistic full-featured digital art software that is used for painting, image editing, vector drawing, free-form transformation, cropping, alpha channel editing, and more specialized tasks.
PixelStyle Photo Editor for Mac is an all-in-one photo editing and graphic design software, providing professional high-quality photo processing tools to edit the photos, enhance and touch up photos on Mac OS X.
DrawPad Graphic Design and Drawing software is an easy-to-use image composition and manipulation program, an essential tool for all types of graphic design projects. Easily draw and create graphic images.
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Tayasui Sketches is a great app for painting and drawing, but it doesn't have the animation features I was looking for.