The best alternative to Wine is PlayOnLinux - PlayOnMac, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 25 alternatives to Wine and nine of them are so hopefully you can find a suitable replacement. Other interesting alternatives to Wine are WinBoat, Bottles, WineBottler and MiceWine.
PlayOnLinux is a graphical frontend for the Wine software compatibility layer which allows Linux and Mac users to install Windows-based video games, Microsoft Office (2000 to 2010), Microsoft Internet Explorer, as well as many other applications.
Runs Windows applications, individual apps, or full desktops inside Linux with native OS-level integration, sleek interface, advanced filesystem sharing, smartcard passthrough, and resource monitoring while supporting simple installation and ongoing feature updates.
WineBottler is an App to manage and wrap your Windows apps into convenient OS X apps. WineBottler helps you with running Windows programs on OS X.
I've used it for many apps
MiceWine is a project that aims to run Windows applications and games on Android smartphones.
Using Wineskin technology, Porting Kit is a PaulTheTall.com app that can install games and apps compiled for Microsoft Windows® in Mac OS X. It has access to a server where we store WSI files for more than 300 games, which can be installed by any Porting Kit user.
Even if Windows supports DirectX natively, using WineD3D can enhance backwards compatiblity with older games, especially on Windows 8 and newer that don't support 16 bit screen modes. Another possible use is to emulate unsupported versions of DirectX, or porting DirectX...
RunApps provides instant browser access to powerful desktop applications like GIMP, LibreOffice, Blender, Audacity, and more. Skip the hassle of downloads and installations—just click and start working.
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PlayOnLinux uses wine technology in a simple, easy to use user interface.