Adobe After Effects is the premiere digital video effects software used industry wide for film making and TV production as well as creative work including high-end video intros and audio-reactive music visualizers.
OpenToonz is an animation program that is a free software version of Toonz, the animation software used by Studio Ghibli, amongst others.
Synfig is a free and open-source, industrial-strength, vector-based 2D animation app designed for producing feature-film animations. It eliminates the need to create animations frame by frame. It is available for Windows, Linux, and macOS.
Enve is a free and open-source 2D animation app. It can create both vector and raster animations and even use sound and video files. It has been created with flexibility and expandability in mind.
Pencil2D is an opensource animation/drawing software for Mac OS X, Windows, and Linux, based on old Pencil software. It lets you create traditional hand-drawn animation (cartoon) using both bitmap and vector graphics.
Adobe Animate, previously Adobe Flash Professional, is an authoring environment (IDE) that can produce interactive solutions for running inside web browsers or for the desktop.
Glaxnimate is a vector graphics animation program which focuses on being quick and easy to use.
Glaxnimate vs Expressive Animator opinions
Can be used free for web graphic animations
Animation Desk is a perfect tool for animating, storyboarding, and sketching. It’s an app Loved by professional and amateur animators, Youtubers, and many art lovers. Draw you frame-to-frame animation from scratch, or create animations upon videos, images, PSD layers.
Tupi is a design and authoring tool for digital artists interested in 2D Animation, fork of the KToon project, offering an interface experience focused on 8-100 years olds.