Dakota is described as 'The Dakota toolkit provides a flexible and extensible interface between simulation codes and iterative analysis methods'. There are eight alternatives to Dakota for Windows, Linux, Mac, BSD and Xfce. The best alternative is R (programming language), which is both free and Open Source. Other great apps like Dakota are RStudio (Free, Open Source), RKWard (Free, Open Source), Minitab (Paid) and R AnalyticFlow (Free).
Chemoface is a novel free user-friendly interface for chemometrics. Chemoface comprises modules that can solve problems related to experimental design, pattern recognition, classification and multivariate calibration.