Cuckoo Sandbox is described as 'modular, automated malware analysis system' and is an app in the OS & Utilities category. There are more than 10 alternatives to Cuckoo Sandbox for a variety of platforms, including Online / Web-based, Windows, Linux, Mac and Python. The best alternative is VirusTotal, which is free. Other great apps like Cuckoo Sandbox are Firejail (Free, Open Source), Hybrid-Analysis.com (Free), SHADE Sandbox (Freemium) and Any.Run (Freemium).
VirusTotal is a free service that analyzes suspicious files and URLs and facilitates the quick detection of viruses, worms, trojans, and all kinds of malware. You can upload files up to 150 MB in size.
FAME is a recursive acronym meaning “FAME Automates Malware Evaluation”. It is meant to facilitate analysis of malicious files, leveraging as much knowledge as possible in order to speed up and automate end-to-end analysis.
Joe Sandbox detects and analyzes potential malicious files and URLs on Windows, Android, Mac OS, Linux, and iOS for suspicious activities. It performs deep malware analysis and generates comprehensive and detailed analysis reports.
Cisco Talos's PyREbox is a python QEMU-based sandbox environment designed to aid in reverse engineering. It can be used for security researchers to aid them in malware analysis, or for general developers with debugging their applications.