VSPE is intended to help software engineers and developers to create/debug/test applications that use serial ports. It is able to create various virtual devices to transmit/receive data.
S-Jinn is a free, lightweight, open-source Linux application written in C. It is a simple command-line tool designed for sending & receiving data from PC controlled TIA/EIA-232 (RS-232) test, measurement, and control devices.
Manta is a tool for moving data between a host machine and a FPGA over UART or Ethernet. It's primarily intended for debugging and rapid prototyping of FPGA designs, but it's robust enough to be used as a simple, reliable transport layer.
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