What is TrueCrypt?
[TrueCrypt is not exactly "Open Source", but the source is available. See the reviews to get more information.]
TrueCrypt is a disk encryption software for Windows Vista/XP, Mac OS X, and Linux. Creates a virtual encrypted disk within a file and mounts it as a real disk.
Encrypts an entire partition or storage device such as USB flash drive or hard drive.
Encrypts a partition or drive where Windows is installed (pre-boot authentication).
Encryption is automatic, real-time (on-the-fly) and transparent.
Parallelization and pipelining allow data to be read and written as fast as if the drive was not encrypted.
Encryption can be hardware-accelerated on modern processors.
Provides plausible deniability, in case an adversary forces you to reveal the password:
Hidden volume (steganography) and hidden operating system.
The development of TrueCrypt was ended in 5/2014 after Microsoft terminated support of Windows XP. Windows 8/7/Vista and later offer integrated support for encrypted disks and virtual disk images. Such integrated support is also available on other platforms. You should migrate any data encrypted by TrueCrypt to encrypted disks or virtual disk images supported on your platform.