Proxmox Virtual Environment is described as 'Complete and easy to use Open Source virtualization platform for running Virtual Appliances and Virtual Machines. Proxmox VE tightly integrates KVM hypervisor and LXC containers, software-defined storage and networking functionality on a single' and is a very popular Virtualization tool in the backup & sync category. There are more than 25 alternatives to Proxmox Virtual Environment for a variety of platforms, including Linux, Self-Hosted, Windows, Mac and Web-based apps. The best Proxmox Virtual Environment alternative is VirtualBox, which is both free and Open Source. Other great apps like Proxmox Virtual Environment are OpenStack, XCP-ng, VMware vSphere Hypervisor and SmartOS.
Use cases have practically no overlap. Proxmox requires dedicated server hardware and is of no use to casual users with desktops, whereas VirtualBox is controlled manually with a GUI and would be highly inconvenient and inefficient for the kind of infrastructure Proxmox is designed for