OpenGL is the premier environment for developing portable, interactive 2D and 3D graphics applications. Since its introduction in 1992, OpenGL has become the industry's most widely used and supported 2D and 3D graphics application programming interface (API), bringing...
Vulkan is a new generation graphics and compute API that provides high-efficiency, cross-platform access to modern GPUs used in a wide variety of devices from PCs and consoles to mobile phones and embedded platforms.
WebGL is a cross-platform, royalty-free web standard for a low-level 3D graphics API based on OpenGL ES 2.0, exposed through the HTML5 Canvas element as Document Object Model interfaces. Developers familiar with OpenGL ES 2.
Simple DirectMedia Layer is a cross-platform multimedia library designed to provide low level access to audio, keyboard, mouse, joystick, 3D hardware via OpenGL, and 2D video framebuffer. It is used by MPEG playback software, emulators, and many popular games, including the...
Allegro 4 and Allegro 5 are cross-platform, libraries mainly aimed at video game and multimedia programming. They handle common, low-level tasks such as creating windows, accepting user input, loading data, drawing images, playing sounds, etc.
OpenGL is a great environment for developing portable, platform independent, interactive 2D and 3D graphics applications. The API implementation in Python is cumbersome, resulting in applications with high latency.
Crystal Space is a mature, full-featured Software Development Kit (SDK) providing real-time 3D graphics for applications such as games and virtual reality. It is free (LGPL) and cross-platform (Windows, GNU/Linux, Mac OS X).
Discontinued since July 2012 : http://www.crystalspace3d.org/main/Download