HyperWorks is described as 'provides the most comprehensive, open-architecture, multiphysics CAE platform to enhance product performance, design lightweight components, get products to the market faster and access to new technologies'. There are six alternatives to HyperWorks for a variety of platforms, including Windows, Linux, Mac, Online / Web-based and GNU Octave. The best alternative is SimScale. It's not free, so if you're looking for a free alternative, you could try Simulation for Design. Other great apps like HyperWorks are COMSOL Multiphysics (Paid), SimFlow (Paid), FEATool Multiphysics (Free Personal) and COSMOSWorks (Paid).
SimFlow is a powerful CFD software, focused on engineering and science. It combines an intuitive user interface with the advantages of the open-source OpenFOAM® libraries in something more than a compact OpenFoam® GUI.
FEATool Multiphysics is a fully integrated Finite Element FEM CAE simulation toolbox for Matlab. With FEATool you can easily model and simulate heat transfer, fluid flow CFD, structural mechanics, chemical reactions, general PDEs, and more.
A simple straightforward process that allows designers to evaluate structural performance of design alternatives quickly and with confidence leveraging commercially proven and robust geometry import, automatic meshing.