HxD is described as 'Carefully designed and fast hex editor which, additionally to raw disk editing and modifying of main memory (RAM), handles files of any size' and is a very popular Hex Editor in the development category. There are more than 50 alternatives to HxD for a variety of platforms, including Windows, Linux, Mac, BSD and Android apps. The best HxD alternative is ImHex, which is both free and Open Source. Other great apps like HxD are dz6, wxHexEditor, 010 Editor and wxMEdit.
ImHex is a free, featureful Hex Editor with many tools often only found in paid products. It includes a custom built scripting language for highlighting and decoding binary data, a disassembler, extensive file analysis tools and much much more
Hex Editor. Support editing or comparing (diff) very large files up to 2^64 bytes. Cross-platform Linux, Mac OS, Windows.
010 Editor is a professional text/hex editor designed to edit any file, drive, or process on your machine. Using Binary Templates technology, 010 Editor allows a binary file to be parsed into a data structure that can be understood.
It's not as smooth to use as HxD, but it natively works in Linux (antiX, a non-systemD distro). E.g., it doesn't copy hex strings, it's necessary to enable hex find/replace in the dialog, close it, then mark the string, and open the find/replace dialog again to be able to copy the hex string (HxD simply copies hex code if it's selected.) It's fast and worked fine with large files (tested with hundreds-MB-size files.)
The Hex Workshop Hex Editor by BreakPoint Software is a complete set of hexadecimal development tools for Microsoft Windows 2000 and later. Hex Workshop combines advanced binary editing and data interpretation with the ease and flexibility of a modern word processor.
Hex workshop has the most extensive sets of tools for looking into hex files and editing them.
Okteta is a simple editor for the raw data of files. This type of program is also called hex editor or binary editor. The data is displayed in the traditional view with two columns: one with the numeric values and one with the assigned characters.
WinHex is a hexadecimal editor capable of opening disks, sectors, files (native support for FAT, NTFS, Ext2/3, ReiserFS, Reiser4, UFS, CDFS, UDF) and physical memory (RAM). It can read, write and extract data for a further forensic analysis.
Hex Editor Neo is a binary files editing software utility for Windows. It's rich and handy set of features will help all software and hardware developers working with ASCII, hex, decimal, float, double and binary data.
Free Hex Editor Neo - Fastest Binary File Editing Software for Windows. Large Files Optimized Freeware Hex Editor
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Does all HxD is capable and more, however, it is worth noting that HxD is a minimal application, lightweight and all, and ImHex requires GPU acceleration... or some software rendering, but still, way heavier.