Xpadder is not available for Mac but there are a few alternatives that runs on macOS with similar functionality. The best Mac alternative is Joystick Mapper. It's not free, so if you're looking for a free alternative, you could try Enjoyable. If that doesn't suit you, our users have ranked more than 10 alternatives to Xpadder and three of them are available for Mac so hopefully you can find a suitable replacement.
Joystick Mapper is an application that allows you to configure your joysticks or gamepads to simulate keyboard keys/mouse movement/mouse click/mouse scroll, so you can control any app or game using them, even the ones without built-in support.
Joystick Mapper vs Xpadder opinions
Most users think Joystick Mapper is a great alternative to Xpadder.