Quassel IRC is described as 'Modern, cross-platform, distributed IRC client based on the Qt5 framework. Distributed means that one (or multiple) client(s) can attach to and detach from a central core that stays permanently online -- much like the popular combination of screen and a' and is a popular IRC Client in the social & communications category. There are more than 50 alternatives to Quassel IRC for a variety of platforms, including Windows, Linux, Mac, Web-based and Self-Hosted apps. The best Quassel IRC alternative is HexChat, which is both free and Open Source. Other great apps like Quassel IRC are WeeChat, Trillian, mIRC and irssi.
jsIRC is written using Socket.IO, node.js, jQuery Title Alert and Sencha ExtJS, relying on string.js, Lo-Dash and PhantomJS.
bIRC is a simple, lightweight and flexible IRC-Client written in Bash. bIRC doesn't require an installation and can be launched by executing a single script file. bIRC has plugin support and can be easily modified.
CGI:IRC is a Perl/CGI program that lets you access IRC from a web browser, it is designed to be flexible and has many uses such as an IRC gateway for an IRC network, a chat-room for a website or to access IRC when stuck behind a restrictive firewall.
Atomic is an open source IRC client built for a new age. New features from its heritage of Yaaic, improvements and stuff.
WebIRC runs as a server and is always connected to your favorite IRC networks. Seamlessly open the same session from home, work, and your mobile devices to continue exactly where you left off.
MegaIRC is an Internet Relay Chat (IRC) Client. It allows you to connect to the IRC network a virtual meeting place where people from all over the world can meet and talk.
jakeIRC is a web-based Meteor IRC client that allows users to connect to their favorite IRC channels.
IceChat is a fully featured, simple to use IRC Client allowing you to chat online with your friends and for meeting new people as well. It can be used in Windows 95/98/ME/2000/XP/2003/Vista and also Windows...
XChat is an IRC chat program for both Linux (Open Source) and Windows (Shareware, 30-day trial). It allows you to join multiple IRC channels (chat rooms) at the same time, talk publicly, private one-on-one conversations etc. Even file transfers are possible.
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