DOE++ is described as 'ReliaSoft's Design of Experiments ( DOE ) software tool, DOE++, supports traditional Design of Experiment methodology and also expands upon the traditional DOE methods to support reliability-DOE, which provides the proper analysis treatment for interval and right-censored'. There are eight alternatives to DOE++ for Windows and Linux. The best alternative is Minitab. It's not free, so if you're looking for a free alternative, you could try Develve or Chemoface. Other great apps like DOE++ are SAS JMP (Paid), The Unscrambler® X (Paid), Design-Expert (Paid) and Statgraphics Centurion XVII (Paid).
Chemoface is a novel free user-friendly interface for chemometrics. Chemoface comprises modules that can solve problems related to experimental design, pattern recognition, classification and multivariate calibration.