Asterogue

Asterogue is a "juicy" graphical coffeebreak roguelike that is pretty much directly inspired by the original Rogue in terms of scope and features. You descend 17 levels into the heart of an asteroid to find The Orb and save the universe. There are a bunch of different monsters which get progressively harder as you descend. Instead of magic there is technology and you can pick up nanotech items and beakers of chemicals to buff your character (or hurt them if you get unlucky).