Shadow Gambit: The Cursed Crew is a real-time tactics video game played from an isometric perspective. The game features eight characters at launch. Each character in the game has their own unique abilities. For instance, Pinkus can briefly possess enemies and enter restricted areas, while Suleidy can distract enemies with plant spores, and spawn a bush anywhere in the game as a hiding spot for other players. Their magical abilities can also be further upgraded by collecting a resource named "vigour". Players will visit the game's various islands multiple times in order to collect Black Pearls, which can be used to resurrect other characters in the game. Characters, once resurrected, will join the player's crew.
Each map in the game is an open region, and players can use a multitude of ways to approach their objectives. While there are multiple ways for players to enter an island, they must escape through "Tear Into The Below", a portal that magically transports the crew back to their ship, the Red Marley, which also serves as the game's hub area. Enemies are alerted to loud noises and footprint, and players need to avoid enemies' sight, which is displayed as green cones of vision. Players can activate Shadow Mode, which briefly pauses the game, allowing players to issue commands to several characters and execute them at once. They can also use the environments to their advantage. For instance, a large boulder can be dropped onto an enemy, killing them without alerting nearby hostile units. The game also features a quick-save system, allowing players to quickly rewind time after making an undesired tactical error.