Sails.js is described as 'make it easy to build custom, enterprise-grade Node.js apps. It is designed to mimic the MVC pattern of frameworks like Ruby on Rails, but with support for the requirements of modern apps: data-driven APIs with scalable, service-oriented architecture' and is an app in the Development category. There are more than 50 alternatives to Sails.js for a variety of platforms, including Mac, Windows, Linux, Online / Web-based and Self-Hosted solutions. The best alternative is ExpressJS, which is both free and Open Source. Other great apps like Sails.js are Meteor (Free, Open Source), Polymer (Free, Open Source), Zepto.js (Free, Open Source) and ember.js (Free, Open Source).
Serenade.js is a client side framework built on the MVC pattern. It makes it simple to create rich client side applications by freeing you from having to keep the DOM up to date with your data through powerful data bindings.
PowerShell Pipeworks is a Framework for making Sites and Services with Windows PowerShell. It is designed to do for web development what PowerShell has done for IT development -- make it easy to build complex solutions out of simple parts.
AmplifyJS is a set of components designed to solve common web application problems with a simplistic API. Amplify's goal is to simplify all forms of data handling by providing a unified API for various data sources.