Mastercam is not available for Mac but there are some alternatives that runs on macOS with similar functionality. The best Mac alternative is MoI - Moment of Inspiration. It's not free, so if you're looking for a free alternative, you could try Ink/Stitch or Embroidermodder. If that doesn't suit you, our users have ranked more than 10 alternatives to Mastercam and six of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to Mastercam are Blender CAM (Free, Open Source), PyCAM (Free, Open Source) and DeskProto (Free Personal).
Embroidermodder is a free machine embroidery software program which allows editing, scaling, and translating sewing machine embroidery files to a variety of formats. It allows the user to add custom modifications to their embroidery designs.
PyCAM is a toolpath generator for 3-axis CNC machining. It loads 3D models in STL format or 2D contour models from DXF or SVG files. The resulting GCode can be used with EMC2 or any other machine controller.
DeskProto is a 3D CAM program (CAM = Computer Aided Manufacturing). It can import STL files from any 3D CAD program, calculate CNC toolpaths and then write NC program files for any brand of CNC milling machine, 3-axis, 4-axis or 5-axis.