Abomination: The Nemesis Project

Abomination takes place in 1999 after the United States has been almost wiped out by a deadly plague. According to the game's manual, the disease started on the east coast, and communication with the west coast ceased within 72 hours. The last few groups of survivors stopped broadcasting after six days, and the overwhelming majority of the country's population has been wiped out.

Most of the remaining survivors have pledged allegiance to an apocalyptic and ultra-violent cult known as "The Faithful", a hazily defined religion whose followers practice mortification of the flesh, as well as vivisecting themselves and others to prove the strength of their beliefs. The Faithful are eventually revealed to be at least several hundred years old, possibly originating from Tibet. The cult predicts the coming of "The Brood" and "the Elder Gods" in a Lovecraftian fashion. The game's backstory also mentions that The Faithful are somehow connected with a strange and very old statuette, called "The Princess of Death", which resembles a cross between a Black Madonna and a prehistoric depiction of the mother goddess. Shortly before the plague first broke out, the US government suspected that the Faithful had either stolen the statue from the unspecified museum where it was kept, or that through their rituals, they caused it to explode there, perhaps disseminating one or more biological agents hidden inside.

The game takes place in a large, unnamed coastal city, which remains mostly undamaged but plagued by odd biological matter, ranging from tentacles growing out of the sidewalk to huge, three-story towers of tissue. The player controls members of "The Nemesis Project", who according to the backstory were originally mustered at a secret base in a fictional location called "Kinmore Field" in Ohio.