The best Programming Language alternative to SigmaPlot is MATLAB. It's not free, so if you're looking for a free alternative, you could try NumeRe. If that doesn't suit you, our users have ranked more than 10 alternatives to SigmaPlot and three of them are Programming Languages so hopefully you can find a suitable replacement.
High-level environment supporting numerical computation, visualization, matrix operations, algorithm development, custom interfaces, integration with external languages, symbolic and model-based simulation, and specialized toolboxes for fields like engineering.
Open source framework for numerical computations and advanced statistical analysis, featuring nonlinear curve fitting, ODE solving, 1D/2D publication-quality visualization, Fourier and wavelet transforms, intuitive syntax, and namespace-based code organization for research.
Doronix Math Toolbox is a numerical computing environment with programming language which can be used as alternative to MATLAB. It allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user functions, import and export CSV-files...
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Even with the statistics package, MATLAB is not nearly as friendly and graph oriented as SigmaPlot. For example, editing statistical graphs for printing or publication is a frustrating endeavor in MATLAB, whereas SigmaPlot is designed specifically for that purpose.