Shortstop

ShortStop is an app for Mac OS X to disable global keyboard shortcuts (hotkeys) so you can interact with the current application unencumbered.

Utility applications add dozens of global keyboard shortcuts to your system. This creates a problem: global keyboard shortcuts that conflict with and override useful local keyboard shortcuts to (e.g. menu commands) in whatever application you’re currently using. The result? You’re going to confuse your computer, your apps, and yourself. This results in lost time, interrupted workflow and reduced efficiency - the exact opposite of what a keyboard shortcut is supposed to accomplish.