MSYS2 is not available for Mac but there are a few alternatives that runs on macOS with similar functionality. The best Mac alternative is PowerShell, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 10 alternatives to MSYS2 and three of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to MSYS2 are SSH Pilot and BossTerm.
PowerShell (including Windows PowerShell and PowerShell Core) is a task automation and configuration management framework from Microsoft, consisting of a command-line shell and associated scripting language built on the .NET Framework.
Desktop SSH manager featuring a user-friendly graphical interface, integrated terminal, tabbed sessions, port forwarding, secure credential storage, SCP upload, keypair generation, privacy controls, customizable appearance options, and .ssh/config import support.
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PowerShell doesn't provide all tools offered msys2+mingw.