DOMtastic is described as 'Small & fast DOM and event library for modern browsers. Having the same familiar API as jQuery (but without the extra "weight" of modules like $.ajax, $.animate, and $.Deferred), it works great stand-alone or paired up with e.g. Backbone' and is an app in the Development category. There are more than 50 alternatives to DOMtastic for a variety of platforms, including Mac, Windows, Linux, Online / Web-based and Self-Hosted solutions. The best alternative is jQuery, which is both free and Open Source. Other great apps like DOMtastic are AngularJS (Free, Open Source), ExpressJS (Free, Open Source), Meteor (Free, Open Source) and Polymer (Free, Open Source).
Expressive middleware for node.js using generators via co to make web applications and APIs more enjoyable to write. Koa's middleware flow in a stack-like manner allowing you to perform actions downstream, then filter and manipulate the response upstream.
Intuitive and Documented It is strongly influenced by jquery with many similar methods so you'll feel at ease developing with Umbrella. However there are also some improvements such as with .ajax(), .append(), etc.
Sails.js make it easy to build custom, enterprise-grade Node.js apps. It is designed to mimic the MVC pattern of frameworks like Ruby on Rails, but with support for the requirements of modern apps: data-driven APIs with scalable, service-oriented architecture.
Opa is an open source, simple and unified platform for writing web applications. All aspects are directly written in Opa: Frontend code, backend code, database queries and configuration. And everything is strongly statically typed.