PrimeSim HSPICE is not available for Mac but there are a few alternatives that runs on macOS with similar functionality. The best Mac alternative is Ngspice, which is both free and Open Source. If that doesn't suit you, our users have ranked five alternatives to PrimeSim HSPICE and three of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to PrimeSim HSPICE are McCAD 3SPICE (Paid) and MacSpice (Free).
Ngspice is a mixed-level/mixed-signal circuit simulator. Its code is based on three open source software packages: Spice3f5, Cider1b1 and Xspice. Ngspice is part of gEDA project, a full GPL'd suite of Electronic Design Automation tools.
McCAD 3-SPICE is based on the latest version (3F5) of Berkeley's SPICE 3 and permits interactive mixed mode circuit simulation. It was developed specifically to take advantage of the processing speeds available thus permitting extremely fast simulations.