The best open source alternative to OsiriX is Horos, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 25 alternatives to OsiriX and eight of them is open source so hopefully you can find a suitable replacement. Other interesting open source alternatives to OsiriX are 3D Slicer (Free, Open Source), Miele-LXIV (Free, Open Source), InVesalius 3 (Free, Open Source) and Weasis (Free, Open Source).
Miele-LXIV is a DICOM workstation, viewer and more. The project started in November 2014 as a fork of the popular open source 32-bit project OsiriX, but it has been modified to become a 64-bit application and to remove many of the limitations of the 32-bit version.
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Most users think Miele-LXIV is a great alternative to OsiriX.
Weasis is a multipurpose standalone and web-based DICOM viewer with a highly modular architecture. It is a very popular clinical viewer used in healthcare by hospitals, health networks, multicenter research trials, and patients.