Derive is not available for Mac but there are plenty of alternatives that runs on macOS with similar functionality. The best Mac alternative is GNU Octave, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 50 alternatives to Derive and many of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to Derive are MATLAB (Paid), Mathematica (Paid), Scilab (Free, Open Source) and SageMath (Free, Open Source).
Octave is a computer program for performing numerical computations which is mostly compatible with MATLAB. It is part of the GNU Project. It is free software under the terms of the GNU General Public License.
MATLAB is a numerical computing environment and programming language. Maintained by The MathWorks, MATLAB allows easy matrix manipulation, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs in other languages.
SageMath is a free open-source mathematics software system licensed under the GPL. It combines the power of many existing open-source packages into a common Python-based interface. Mission: Creating a viable free open source alternative to Magma, Maple, Mathematica and Matlab.
Maxima is a system for the manipulation of symbolic and numerical expressions, including differentiation, integration, Taylor series, Laplace transforms, ordinary differential equations, systems of linear equations, polynomials, and sets, lists, vectors, matrices, and tensors.
Orange is an open-source, cross-platform data mining and machine learning suite. It features visual programming as intuitive means of combining data analysis and interactive visualization methods into powerful workflows.
wxMaxima is a document based interface for the computer algebra system Maxima. wxMaxima uses wxWidgets and runs natively on Windows, X11 and Mac OS X. wxMaxima provides menus and dialogs for many common maxima commands, autocompletion, inline plots and simple animations.
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wxMaxima vs Derive opinions
pros, cons and recent comments
Whilst wxMaxima is not as powerful nor as thorough as some of the other systems, it is very simple to use, and is perhaps the most similar in syntax to the derive library.
SymPy is a Python library for symbolic computation. The stated goals of the library are to become a full-featured computer algebra system and to keep a simple code base to promote extensibility and comprehensibility.