Anno is not available for Mac but there are some alternatives that runs on macOS with similar functionality. The best Mac alternative is CaesarIA, which is both free and Open Source. If that doesn't suit you, our users have ranked more than 10 alternatives to Anno and six of them are available for Mac so hopefully you can find a suitable replacement. Other interesting Mac alternatives to Anno are Dune Legacy (Free, Open Source), Tropico (Paid), Spring 1944 (Free, Open Source) and Warhammer 40,000: Dawn of War (Paid).
CaesarIA is an open source remake of Caesar III game released by Impressions Games in 1998, it aims to expand the possibilities of the classical city-building simulators and to add new features showing the city life. Now the game work with Windows, Linux, Mac, Haiku and Android.
Tropico is a series of construction and management simulation computer games developed by PopTop Software and published by Gathering of Developers in April 2001. Feral Interactive has developed and published a number of the games. Represent entire series of Tropico games.
Warhammer 40,000: Dawn of War is a military science fiction real-time strategy video game developed by Relic Entertainment and based on Games Workshop's tabletop wargame Warhammer 40,000. Represent entire series of Warhammer 40,000: Dawn of War games including Warhammer 40,000: Dawn of War, Warhammer 40,000: Dawn of War II, Warhammer 40,000: Dawn of War III.
Tentlan is a free strategy real-time online game played in the times of the pre-Columbian Americas. Starting off with a small settlement in the rainforest, you will gather power and influence till you end up developing a great maya empire.