Apps with 'Disable Keyboard Keys' feature

SharpKeys is a utility that manages a Registry key that allows Windows to remap one key to any other key. Included in the application is a list of common keyboard keys and a Type Key feature to automatically recognize most keyboard keys. It was developed in C# using .NET v2.

dWinlock is a portable, easy to use program (trial version, but fully functional, limited only by a warning message) and allows you to disable certain functions and key combinations of windows.

ShortStop is an app for Mac OS X to disable global keyboard shortcuts (hotkeys) so you can interact with the current application unencumbered.

KillKeys exist so that you can play games without having to worry about accidentally pressing the windows key. The keys essentially becomes dead keys.