There are many alternatives to SpatiaLite for Mac if you are looking for a replacement. The best Mac alternative is PostGIS, which is both free and Open Source. If that doesn't work for you, our users have ranked three alternatives to SpatiaLite, but unfortunately only two of them are available for Mac. If you can't find an alternative you can try to remove all filters.
PostGIS adds support for geographic objects to the PostgreSQL object-relational database. In effect, PostGIS "spatially enables" the PostgreSQL server, allowing it to be used as a backend spatial database for geographic information systems (GIS), much like ESRIs SDE...
H2GIS is a spatial extension of the H2 Database Engine in the spirit of PostGIS . It adds support for managing spatial features and operations including a Geometry constraints, the Open Geospatial Consortium...
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PostGIS is targeting a different database - PostgreSQL