AutoCAD is a CAD application for 2D and 3D design and drafting for high-end professionals.
It is the industry leader in the CAD software and its DWG file format has been widely adopted.
AutoCAD offers an extensive API for extensions and custom objects, a modern 3D rendering engine and modeling tools, and several import and export options.
Autodesk sells various versions of AutoCAD with official prices starting at $4000 for AutoCAD 11. Free 30-day trial with registration.
AutoCAD for Mac has been announced for Q4 2010.