The best open source alternative to ACD/ChemSketch is Avogadro. If that doesn't suit you, our users have ranked more than 10 alternatives to ACD/ChemSketch and eight of them is open source so hopefully you can find a suitable replacement. Other interesting open source alternatives to ACD/ChemSketch are ChemistryLab, JChemPaint, BKchem and ChemCanvas.
Avogadro is an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas.
ChemistryLab is a chemical laboratory simulation application designed for the Android platform. It serves as a derivative version of the original ChemistryLab, developed by Tran Thanh Tùng, maintaining the same functionality while introducing modifications to the user...
JChemPaint (or JCP for short here) is the editor and viewer for 2D chemical structures developed using the Chemistry Development Kit (CDK).
BKChem is a free (as in free software :o) chemical drawing program. It was conceived and written by Beda Kosata and is currently maintained by Reinis Danne.
MollyCule is a completely free Open Source Chemistry visualisation program for MacOS, Linux and Windows. MollyCule is designed to be a nice, easy to use program to help ordinary people who want to explore Chemistry.
XDrawChem is a free software program for drawing chemical structural formulas, available for Unix and Mac OS. It is distributed under the GNU GPL. In Microsoft Windows this program is called WinDrawChem.
The Gnome Chemistry Utils include six chemistry related programs:
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