Twhirl is a social software desktop client, based on the Adobe AIR platform. Can connects to multiple Twitter, laconi.ca, Friendfeed and Seesmic accounts. Shorten long URLs (using bit.ly, snurl, twurl or is.gd). Cross-post your updates to Jaiku and many other sites like Facebook, MySpace, LinkedIn and more via Ping.fm. More info »
Digsby is a multiprotocol IM client that lets you chat with all your friends on AIM, MSN, Yahoo, ICQ, Google Talk, and Jabber with one simple to manage buddy list. It's also a social networking tool that alerts you of ev ...
A very polished application to manage multiple Twitter-accounts on your mac. This native OS X application is an offspring from the very popular iPhone version with the same name. There is a free verison that contain a fe ...
TweetDeck is an Adobe Air desktop application that is currently in public beta. It aims to evolve the existing functionality of Twitter by taking an abundance of information i.e twitter feeds, and breaking it down into m ...
DestroyTwitter is a robust but compact Twitter application built to run on Mac, Windows, and Linux using Adobe AIR. It consists of a series of canvases that constantly update to keep tweets current and up-to-date using n ...
Stay on top of your Twitter timeline with Echofon for Mac. The beautiful, subtle interface will be a welcome addition to your Mac’s desktop.
The Nambu Network is creating the best possible social messaging experience: seemlessly integrated with a superior look and feel. Nambu OS X is still in beta, but progressing quickly.
HootSuite is the ultimate Twitter toolbox. With HootSuite, you can manage multiple Twitter profiles, add multiple editors, pre-schedule tweets, and measure your success. HootSuite lets you manage your entire Twitter e ...
Twitterrific is a fun application that lets you both read and publish posts or "tweets" to the Twitter community website. The applications user interface is clean, concise and designed to take up a minimum of r ...
Gwibber is an open source microblogging client for GNOME developed with Python and GTK. It supports Twitter, Jaiku, Identi.ca, Facebook, Flickr, Digg, and RSS.
Get live updates from your friends on Twitter and Facebook. Easily and quickly share links, pictures and video with your friends. Group your social contacts into lists like family, co-workers and best friends.
Socialite is designed to make it easy to stay in touch with the social networks and services that matter to you. From news on Digg, photos on Flickr, statuses and photos on Facebook and Twitter updates, to full Google Re ...
Skimmer is an Adobe AIR desktop application designed to streamline, beautify, and enhance the experience of participating in your most frequently used social networking activities. It improves upon day-to-day interaction ...
Seesmic for Windows is a native Windows Twitter client, currently in beta, which is based on Seesmic Desktop (which uses Adobe Air).
Spaz is a Twitter client for users who value free, open-source software, attractive design, and customizability
Choqok - KDE Micro-Blogging Client
We know an awful lot about software but not everything. We would be happy if you could tell us with a few words why is not an alternative to .